HIV

$20 million Research Project to Explore a Potential Cure for HIV Infection

July 11, 2011

Fred Hutchinson Cancer Research Center to lead a $20 million research project to explore a potential cure for HIV infection.  The five-year federally funded study will test transplantation of gene-modified cells.  One approach under investigation is autologous stem cell transplantation, in which the infected patient’s own immune cells are genetically modified to be resistant to [...]

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Study: Umbilical Cord Mesenchymal Stem Cells for Immune Reconstitution in HIV-infected Patients

July 5, 2011

Phase 1/2 Study of UC-MSC in Restoring CD4 T Cell Counts and Reducing Immune Activation in HIV-infected Patients Underlying Long-term Antiviral Therapy. HIV-1 infection is characterized by progressive depletion of CD4+ T cells that eventually leads to clinically significant immunodeficiency. A chronic generalized immune activation is now being recognized to be the main driving force [...]

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Evidence for the cure of HIV infection by CCR5[delta]32 / [delta]32 stem cell transplantation

January 5, 2011

Abstract HIV entry into CD4+ cells requires interaction with a cellular receptor, generally either CCR5 or CXCR4. We have previously reported the case of an HIV-infected patient in whom viral replication remained absent despite discontinuation of antiretroviral therapy after transplantation with CCR5[delta]32/[delta]32 stem cells. However, it was expected that the long-lived viral reservoir would lead [...]

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