Researchers at the University of Texas Health Science Center in Houston are preparing to conduct a study on the use of stored umbilical-cord blood cells to treat traumatic brain injury in children. A similar study conducted earlier using bone marrow stem cells yielded positive results, the researchers said.
Traumatic brain injury (TBI) contributes to 50% of all trauma deaths. The mortality rate for children following severe TBI (Glasgow Coma Scale < 9) ranges from 14-24%. There is currently no therapy to reverse the primary injury associated with TBI. Cord-Blood contains mesenchymal stem cells (MSC) and hematopoetic stem cells (HSC). These cells are a component of cord-blood that preferentially migrate to the site of brain injury and differentiate into neurons and cell supporting elements, improving functional outcome in animals.